The Bayer Agricultural Center in Monheim is the headquarters of Bayer CropScience, from where the global activities of the subgroup are directed. Monheim also houses Bayer's biggest research center for crop science.

As the operator of the Bayer Industrial Park Brunsbüttel, Bayer MaterialScience produces raw materials for rigid and flexible polyurethane foam materials. Many partners have set up business on the site. These include CFB Chemische Fabrik Brunsbüttel, IndustriePark Logistik Brunsbüttel, Spedition F. A. Kruse, Lanxess, Linde Gas, TÜV SÜD Chemie Service, Vesta Biofuels Brunsbüttel, VSU Vereinigte Sicherheitsunternehmen, Bayer Gastronomie and other contracting companies for maintenance and engineering services. Some 1,150 people work at the Brunsbüttel site.

Bayer`s history began in Wuppertal a former center of the dyestuff industry. The general partnership "Friedr. Bayer et comp." was founded on August 1, 1863, in Wuppertal-Barmen by Friedrich Bayer und Friedrich Weskott. Since the establishment of the Bayer Pharmaceutical Research Center in 1967, Wuppertal has been one of the most important research sites of Bayer HealthCare.